People

Daniel Garrigan

People

Contact Information

Daniel Garrigan
Assistant Professor
Office: Hutchison 319
Phone: (585) 276-4816
Email: daniel.garrigan@rochester.edu
Lab Website
Research Interests: Computational biology; Evolutionary biology; Genomics  

Research Overview

What features of genome sequences make species distinct biological entities? Our laboratory harnesses the power of comparative population genomics to study speciation and adaptation in a variety of model organisms. Comparative population genomics (CPG) is the study of genome-wide variation in two populations of closely related taxa or species. CPG allows us to identify which genomic features remain distinct between species and which are free to move between species via migration and gene flow.

We also use CPG approaches to study piwi-RNA and transposable element evolutionary dynamics in Drosophila, small RNA-mediated epigenetic inheritance, the evolution of de novo genes, and modes of natural selection in Caenorhabditis elegans.

chromosomes

Selected Publications

  • Kingan, S.B., Geneva, A.J., Vedanayagam, J.P. and Garrigan, D. 2014. Genome divergence and introgression between Drosophila simulans and D. mauritiana. PLoS Genetics: in review.
  • Garrigan, D., Kingan, S.B., Geneva, A.J., Vedanayagam, J.P. and Presgraves, D.C. 2014. Genome diversity and divergence in Drosophila mauritiana: multiple signatures of faster X evolution. Genome Biol. Evol.: in press.
  • Vedanayagam, J.P. and Garrigan, D. 2014. The evolutionary rate of proteins with large phenotypic effects in Drosophila melanogaster. G3: in review.
  • Geneva, A.J., Kingan, S.B. and Garrigan, D. 2014. A new method to scan genomes for introgression in a secondary contact model. Heredity: in review.
  • Brand, C.L., Kingan, S.B., Wu, L. and Garrigan, D. 2013. A selective sweep across species boundaries in Drosophila. Mol. Biol. Evol. 30: 2177-2186.
  • Garrigan, D. 2013. POPBAM: tools for evolutionary analysis of short read sequence alignments. Evol. Bioinform. 9: 343-353.
  • Garrigan, D., Kingan, S.B., Geneva, A.J., Andolfatto, P., Clark, A.G., Thornton, K.R. and Presgraves, D.C. 2012. Genome sequencing reveals complex speciation in the Drosophila simulans clade. Genome Res. 22: 1499-1511.
  • Kingan, S.B., Garrigan, D. and Hartl, D.L. 2010. Recurrent selection on the Winters sex-ratio genes in Drosophila simulans. Genetics 184: 253-265.