Page 10 - In Motion - Spring 2021 Volume 17 | UR Medicine
P. 10
CMSR alumni who now lead orthopaedic
departments at leading academic medical CMSR Timeline
centers are Regis O’Keefe, M.D., Ph.D.,
(Washington University at St. Louis),
1940s-1950s
James O. Sanders, M.D., (University of URMC faculty member William F.
North Carolina), Stephen Kates, M.D., Neuman, Ph.D.–co-founder and ultimate 1979
(Virginia Commonwealth University), and chair of Department of Biophysicis - Chair of Orthopaedic Surgery,
Kevin Black, M.D. (Pennsylvania State begins research in mineral metabolism. Dr. C. McCollister Evarts, recruits a
University). In 1958 he and his wife, Dr. Margaret Neuman trainee, Dr. John Brand, to
Neuman, publish the seminal text “The lead the newly formed Orthopaedic
In its 21st year, CMSR’s main focus is on Chemical Dynamics of Bone Mineral.” Research Laboratory.
renewal of that P30 grant, an award it first
earned while Rosier led the center. 1981
Chair of Orthopaedics Dr. Richard Burton 1984
recruits Dr. J. Edward Puzas, a former
“We have many grants at the Center, but trainee of Brand, who builds programs Dr. Randy Rosier recruited as
the P30 is the backbone,” Schwarz said. focused on understanding bone matrix and the first clinician scientist; he
“It’s an infrastructure grant that doesn’t the osteoblastic cells that produce it. initiates the cartilage biology
directly fund research but makes our program, focusing on growth factor
regulation of the growth plate.
research possible.”
2000
Years of focus on recruitment and growth
culminate in Rosier’s appointment as 2002
“ [Our mission is] to advance Chair of the Department of Orthopaedics Dr. Puzas earns a Program Project Grant
& Rehabilitation and Director of the new
examining the molecular basis of the
our faculty members to Center for Musculoskeletal Research. toxic effect of Pb on the skeleton.
independence, establishing 2003
them as national leaders and CMSR takes its place as one of the
the most desirable faculty in top five NIH-funded musculoskeletal
research centers in the U.S., a
their field by the top academic 2006 distinction that has continued
programs in the country, upon Drs. O’Keefe and Michael Zuscik secure uninterrupted for the past two
a ‘Training in Orthopaedic Research’ decades. In five of those years, CMSR
which the ultimate success of T32 training grant that supports earned the coveted, highly competitive
CMSR’s efforts to recruit the most
this Center will be judged. ” promising talent from diverse pools #1 spot for NIH funding.
of graduate students across the U.S.
CMSR’s 800-page grant renewal 2011
application outlines how it maximized 2012 Drs. Rosier and Regis O’Keefe, who
succeeded Rosier as director of CMSR,
the value of P30 pilot grant funding. Dr. Schwarz is appointed director of secure a Center of Research Translation
“It all goes back to the foundation that CMSR, focusing on inflammatory bone (CORT) grant aimed at translating
loss, infections, tumor metastasis and
Rosier and CMSR’s early architects and wear debris-induced osteolysis around molecular signaling pathways into
champions built, and the original mission loose prosthetic implants. orthopaedic trauma care.
statement written in the first P30 grant, Dr. Edward Schwarz earns a
which remains: to advance our faculty TODAY Core Center Grant P30 from the
National Institute of Arthritis and
members to independence, establishing CMSR’s growth and global influence on Musculoskeletal and Skin Diseases
them as national leaders and the most musculoskeletal research continue: it has for 2011-2021, which provides robust
desirable faculty in their field by the top 41 regular faculty, 36 new/early stage funding for research as well as for the
investigators (N/ESI) and more than 100
academic programs in the country, upon scientists occupying greater than 22,000 development of research scientists
early in their careers.
which the ultimate success of this Center square feet of lab and office space at
will be judged,” Schwarz said. URMC. It published 253 peer-reviewed
research papers in 2020.
10 In Motion | UR Medicine Orthopaedics & Physical Performance | Spring 2021
